Pola Wrinkle Shot Medical Serum Duo Single Set 15mL

About Product

POLA Wrinkle Shot Medical Serum Duo – Single Set (15mL)

Japanese Anti-Wrinkle Serum | Full-Face Wrinkle Care | NEI-L1® | Two-Part Mixing Formula

Discover a new approach to full-face wrinkle care with POLA Wrinkle Shot Medical Serum Duo, an innovative Japanese anti-wrinkle serum featuring POLA's proprietary active ingredient NEI-L1®.

Unlike conventional wrinkle serums, Medical Serum Duo uses a unique two-part formula that is mixed before use. This technology allows POLA to incorporate its delicate wrinkle-improving ingredient into a fresh, lightweight serum that spreads comfortably across the entire face.

Designed to address wrinkles appearing in different areas of the face, the serum combines clinically recognised Japanese quasi-drug wrinkle care with moisturising ingredients for smoother, firmer and more radiant-looking skin.

What's Included?

Important: The two formulas must be mixed before use. This is a single-set product containing one complete 15mL serum preparation.

Key Benefits

• Approved wrinkle improvement: Contains POLA's proprietary active ingredient NEI-L1®, approved in Japan for improving wrinkles.

• Full-face application: Designed to spread easily over the entire face rather than only individual wrinkle-prone areas.

• Innovative two-part formula: Separates the ingredients until mixing to accommodate the water-sensitive properties of NEI-L1®.

• Fresh, lightweight texture: Glides smoothly across the skin and absorbs quickly.

• Firming-feel veil: Creates a smooth, supple finish with a feeling of firmness.

• Moisturising care: Features three POLA-exclusive moisturising complexes and Moist Catcher.

• Smooth, radiant appearance: Helps skin feel hydrated and look firmer, smoother and more luminous.

What Makes POLA Wrinkle Shot Medical Serum Duo Different?

1. NEI-L1® – POLA's Proprietary Wrinkle-Improving Ingredient

At the heart of Medical Serum Duo is NEI-L1®, an active ingredient independently developed by POLA for wrinkle improvement.

POLA's wrinkle research focuses on neutrophil elastase, an enzyme associated with wrinkle formation.

Building on its research, POLA identified the presence of neutrophil elastase across various facial areas and developed Medical Serum Duo to support a more comprehensive approach to wrinkle care.

The serum is classified as a Japanese quasi-drug, with NEI-L1® as its approved wrinkle-improving active ingredient.

2. Full-Face Care for Scattered Wrinkles

POLA introduces the concept of scattered wrinkles—dermal wrinkles that appear across different areas of the face.

These wrinkles may:

• Develop in areas that are not immediately noticeable.

• Remain visible even when the face is relaxed.

• Occur in areas exposed to relatively gentle facial-expression pressure.

Rather than concentrating exclusively on individual lines, Medical Serum Duo is designed for convenient application across the entire face.

Its fluid consistency makes it easier to incorporate wrinkle care into a daily skincare routine.

3. Wrinkle Shot Mix Formula – Innovative Two-Part Technology

NEI-L1® is a delicate ingredient that gradually breaks down when exposed to water.

To create a fresh, water-rich texture suitable for full-face use, POLA developed its proprietary Wrinkle Shot Mix Formula.

The product contains two separate preparations:

Formula A – 1.5mL

Supplied in a glass bottle.

Formula B – 13.5mL

Supplied in a tube.

The two preparations are mixed by the user before application, creating the finished serum.

POLA states that the two-part mixing format received its first Japanese approval as a wrinkle-improving quasi-drug in March 2024.

This innovative system makes it possible to enjoy NEI-L1® in a lightweight serum texture designed for full-face application.

4. Moist Fresh Texture – Lightweight, Smooth and Comfortable

Medical Serum Duo features a Moist Fresh Texture that combines a refreshing feel with a soft, smooth finish.

The serum:

• Spreads easily across the entire face.

• Blends quickly into the skin.

• Feels fresh and comfortably moisturising.

• Leaves skin feeling smooth and supple.

• Supports a firmer, more radiant-looking complexion.

Its lightweight consistency makes it particularly suitable for those who prefer full-face wrinkle care without a heavy cream texture.

5. Firming Veil and Moist Catcher Technology

POLA designed the formula to create a delicate veil over the skin, helping deliver a smooth finish with a feeling of firmness.

The serum also contains Moist Catcher, a moisturising ingredient that supports the skin's hydration.

Moist Catcher Ingredient: Polyglyceryl-3 Methylglucose Distearate

Together, these features help create a comfortable, moisturised and smooth skin feel.

Featured Ingredients

NEI-L1® – Active Wrinkle-Improving Ingredient

POLA's proprietary ingredient approved in Japan for wrinkle improvement.

Full Ingredient Name: Sodium Trifluoroisopropyl Oxopropylaminocarbonyl Pyrrolidinecarbonyl Methylpropylaminocarbonyl Benzoylaminoacetate.

Ni-Renergy – POLA Original Moisturising Complex

A proprietary moisturising combination of:

• Birch Extract

• Eucalyptus Extract

D Liquid – POLA Original Moisturising Complex

A proprietary moisturising combination of:

• Kouki Extract-2

• Linden Extract

NERE Liquid N – POLA Original Moisturising Complex

A proprietary moisturising combination of:

• Oil-Soluble Peach Leaf Extract

• Horsetail Extract

Moist Catcher

Polyglyceryl-3 Methylglucose Distearate

A moisturising ingredient incorporated into the serum's formulation.

These ingredients complement the wrinkle-improving active ingredient by supporting hydration and a supple skin feel.

How to Use POLA Wrinkle Shot Medical Serum Duo

Step 1 – Mix the Two Formulas

Before the first application, combine Formula A (1.5mL) and Formula B (13.5mL) according to POLA's official mixing instructions.

Attach the supplied nozzle and cap as directed.

Important: Follow the product's official instructions for the exact mixing procedure, handling and use period after mixing.

Step 2 – Apply After Cleansing

Medical Serum Duo is a pre-lotion serum.

Use it after washing your face and before applying facial lotion or toner.

Step 3 – Apply Across the Entire Face

Spread the prepared serum gently and evenly across the face.

Its lightweight, moisturising texture is designed to blend quickly and comfortably into the skin.

Step 4 – Continue Your Skincare Routine

Follow with your usual facial lotion and other skincare products.

For detailed mixing instructions and the complete ingredient list, scan the QR code printed on the product's outer packaging to access POLA's official digital leaflet.

Medical Serum Duo vs Medical Serum N

Both products belong to POLA's Wrinkle Shot range and feature the proprietary active ingredient NEI-L1®, but their formats and intended application styles differ.

Choose Medical Serum Duo if you want to incorporate NEI-L1® into a lightweight, full-face skincare routine.

Choose Medical Serum N if you prefer a ready-to-use product for targeted wrinkle care.

Consideration for Skin Sensitivity

POLA states that Medical Serum Duo has been allergy tested.

However, this does not guarantee that allergic reactions will not occur in every individual.

If you have particularly sensitive skin or a history of reactions to skincare ingredients, review the complete ingredient list before use.

Sustainability and Packaging

POLA has incorporated several environmentally conscious elements into Medical Serum Duo's packaging:

• Bio-based ink used for the outer carton.

• Forest-certified paper used for the outer carton.

• Renewable transparent glass used for the container.

• Bio-based polyethylene (Bio-PE) used in the packaging.

• Digital product leaflet accessible via the QR code on the outer carton.

These choices reflect POLA's efforts to reduce the environmental impact of its product packaging.

Product Details

Frequently Asked Questions

What is POLA Wrinkle Shot Medical Serum Duo?

It is a Japanese anti-wrinkle facial serum featuring POLA's proprietary active ingredient NEI-L1®. The product uses a two-part mixing formula to create a lightweight serum designed for full-face application.

What is the difference between Medical Serum Duo and Medical Serum N?

Medical Serum Duo is designed for full-face use and requires mixing two formulas before application. Medical Serum N is a ready-to-use product intended for more targeted wrinkle care. Both contain NEI-L1®.

Why does Medical Serum Duo need to be mixed?

NEI-L1® gradually breaks down when exposed to water. POLA developed the two-part Wrinkle Shot Mix Formula to accommodate this ingredient while creating a fresh, lightweight texture suitable for the entire face.

Does POLA Wrinkle Shot Medical Serum Duo improve wrinkles?

Yes. The serum contains NEI-L1®, an active ingredient approved in Japan for wrinkle improvement. Results vary between individuals.

Can I use Medical Serum Duo on my entire face?

Yes. Medical Serum Duo is specifically formulated to spread comfortably across the entire face.

Should I use Medical Serum Duo before or after toner?

Use Medical Serum Duo after cleansing and before facial lotion or toner.

How much product is included in the single set?

The set contains 15mL in total, consisting of Formula A (1.5mL) and Formula B (13.5mL), plus a nozzle and cap.

Is Medical Serum Duo suitable for sensitive skin?

The product has been allergy tested, but this does not guarantee that every user will be free from allergic reactions.

Where can I find the mixing instructions?

POLA provides a digital product leaflet. Scan the QR code on the outer carton to access detailed mixing instructions, product information and the full ingredient list.