Pola Wrinkle Shot Medical Serum Duo 3 Set 45mL

About Product

POLA Wrinkle Shot Medical Serum Duo – 3 Set (45mL)

Japanese Anti-Wrinkle Serum | NEI-L1® | Full-Face Wrinkle Care | Three Two-Part Serum Sets

Discover comprehensive wrinkle care with POLA Wrinkle Shot Medical Serum Duo 3 Set, featuring three complete preparations of POLA's innovative anti-wrinkle serum.

Developed for wrinkles that appear across different areas of the face, Medical Serum Duo combines POLA's proprietary wrinkle-improving active ingredient NEI-L1® with a lightweight, moisturising texture that spreads smoothly over the entire face.

Its distinctive two-part mixing formula is designed around the delicate properties of NEI-L1®, allowing the active ingredient to be incorporated into a fresh, comfortable serum for full-face application.

This three-set format contains 45mL in total, divided into three individually prepared 15mL sets, making it a convenient choice for those looking to incorporate full-face wrinkle care into their regular skincare routine.

What's Included?

Each complete preparation consists of Formula A (1.5mL) and Formula B (13.5mL), providing 15mL of serum after mixing.

Important: Each pair of formulas must be mixed before use according to POLA's official instructions. The three-set package contains three complete preparations, not one premixed 45mL bottle.

Key Benefits

• Wrinkle improvement: Contains POLA's proprietary active ingredient NEI-L1®, approved in Japan for improving wrinkles.

• Full-face wrinkle care: Designed for wrinkles appearing across different facial areas.

• Innovative mixing technology: Uses two separately packaged formulas that are combined before use.

• Lightweight, moisturising texture: Spreads easily and blends quickly into the skin.

• Smoother-looking complexion: Creates a comfortable veil with a feeling of firmness.

• Hydrating formula: Includes three POLA-original moisturising complexes and Moist Catcher.

• Three complete sets: Provides a total of 45mL for continued skincare use.

POLA's Approach to Full-Face Wrinkle Care

NEI-L1® – Proprietary Wrinkle-Improving Active Ingredient

POLA Wrinkle Shot Medical Serum Duo features NEI-L1®, an active ingredient independently developed by POLA and approved in Japan for wrinkle improvement.

POLA's research focuses on neutrophil elastase, an enzyme associated with wrinkle formation.

The brand has also investigated the presence of neutrophil elastase across different facial areas, informing its approach to wrinkles that develop throughout the face.

Medical Serum Duo is designed to make NEI-L1® convenient to apply over the entire face, rather than focusing solely on individual lines.

Japanese Classification: Quasi-Drug
Active Ingredient: NEI-L1®

What Are Scattered Wrinkles?

POLA uses the term scattered wrinkles to describe dermal wrinkles that develop in different areas of the face.

These wrinkles may be:

• Difficult to notice because they appear in unexpected areas.

• Visible even when facial muscles are relaxed.

• More likely to develop in areas exposed to relatively gentle facial-expression pressure.

POLA's Smoothing Dynamism Theory explores the relationship between neutrophil elastase and wrinkle formation across the face.

The resulting serum is designed to support smoother, firmer-looking skin through a combination of approved wrinkle-improving care and moisturising ingredients.

Wrinkle Shot Mix Formula – Why Two Preparations?

NEI-L1® is a delicate ingredient that gradually breaks down when exposed to water.

To create a water-rich texture suitable for full-face application, POLA developed its proprietary Wrinkle Shot Mix Formula.

The product separates its formula into two components that are mixed by the user before application.

This approach allows the finished serum to offer a fresh, lightweight consistency while incorporating NEI-L1®.

POLA states that this two-part mixing system received Japan's first approval for a wrinkle-improving quasi-drug of its kind in March 2024.

Each Set Contains

Formula A – 1.5mL

Supplied in a glass bottle.

Formula B – 13.5mL

Supplied in a tube.

Accessories

One nozzle and one main cap for each complete preparation.

The three-set package includes three of each component.

Moist Fresh Texture – Smooth, Lightweight Application

Medical Serum Duo features POLA's Moist Fresh Texture, designed to spread gently and evenly across the face.

The formula has a fresh, soft consistency that blends quickly into the skin, leaving a comfortable, moisturised finish.

Rather than feeling like a heavy treatment cream, it is designed for easy full-face application.

With regular use, the serum aims to support skin that feels smoother and more supple, with a firmer, radiant-looking appearance.

Firming Veil Design

POLA has also incorporated a veil-forming design that creates a feeling of firmness on the skin.

The formula is intended to leave a smooth, comfortable finish while supporting the appearance of supple, hydrated skin.

A moisturising ingredient called Moist Catcher is included to complement this formulation.

Featured Ingredients

NEI-L1® – Wrinkle-Improving Active Ingredient

POLA's proprietary active ingredient approved in Japan for wrinkle improvement.

Full Ingredient Name: Sodium Trifluoroisopropyl Oxopropylaminocarbonyl Pyrrolidinecarbonyl Methylpropylaminocarbonyl Benzoylaminoacetate.

Ni-Renergy – Original Moisturising Complex

A combination of:

• Birch Extract

• Eucalyptus Extract

D Liquid – Original Moisturising Complex

A combination of:

• Kouki Extract-2

• Linden Extract

NERE Liquid N – Original Moisturising Complex

A combination of:

• Oil-Soluble Peach Leaf Extract

• Horsetail Extract

Moist Catcher

Polyglyceryl-3 Methylglucose Distearate

A moisturising ingredient incorporated into the serum's formulation.

Together, these moisturising components complement NEI-L1® by supporting hydration, softness and a supple skin feel.

How to Use

Step 1 – Prepare One Serum Set

Take one Formula A (1.5mL) and one Formula B (13.5mL).

Mix the two preparations according to POLA's official instructions, using the supplied accessories.

Do not combine all three sets at once unless explicitly directed by the manufacturer.

Follow POLA's instructions for preparation, handling and the recommended use period after mixing.

Step 2 – Apply After Cleansing

Medical Serum Duo is designed as a pre-lotion serum.

Apply it after cleansing and before facial lotion or toner.

Step 3 – Spread Across the Face

Gently distribute the prepared serum over the entire face.

Its lightweight texture is designed to spread smoothly and blend quickly into the skin.

Step 4 – Continue Your Skincare Routine

Follow with your usual lotion, moisturiser and other skincare products.

For complete mixing instructions and the full ingredient list, consult the official product information supplied with the package.

Medical Serum Duo – 3 Set vs Single Set

Both versions contain the same serum formula and use the same two-part mixing technology. The difference is the number of complete preparations included.

The Single Set is a practical introduction to the formula.

The 3 Set provides three complete preparations for customers who wish to continue using Medical Serum Duo as part of their skincare routine.

Packaging and Environmental Considerations

POLA incorporates several environmentally conscious packaging choices into Medical Serum Duo:

• Bio-based ink for the outer carton.

• Forest-certified paper for the outer carton.

• Renewable transparent glass for the container.

• Bio-based polyethylene (Bio-PE) packaging components.

• A digital product leaflet in place of a conventional printed brochure.

The digital leaflet provides detailed product information and instructions.

Product Details

Frequently Asked Questions

What is included in POLA Wrinkle Shot Medical Serum Duo 3 Set?

The package contains three Formula A glass bottles (1.5mL each), three Formula B tubes (13.5mL each), and three sets of nozzles and caps. The total serum volume is 45mL.

Is the 3 Set different from the Single Set?

The serum formula is the same. The 3 Set contains three complete 15mL preparations, while the Single Set contains one.

Why does POLA Medical Serum Duo require mixing?

NEI-L1® gradually breaks down when exposed to water. POLA developed its two-part mixing formula to accommodate this ingredient while creating a fresh, lightweight serum suitable for full-face application.

Can Medical Serum Duo be applied to the entire face?

Yes. Medical Serum Duo is specifically designed for full-face application, including areas where wrinkles may be less noticeable.

Does POLA Wrinkle Shot Medical Serum Duo improve wrinkles?

The serum contains NEI-L1®, an active ingredient approved in Japan for wrinkle improvement. Individual results may vary.

When should I apply Medical Serum Duo?

Use it after cleansing and before facial lotion or toner.

Should I mix all three sets at once?

Prepare each complete 15mL set according to POLA's instructions. Do not mix all three preparations together unless the manufacturer specifically instructs you to do so.

What is the difference between Medical Serum Duo and Medical Serum N?

Medical Serum Duo uses a two-part mixing formula with a lightweight texture intended for full-face application. Medical Serum N is a ready-to-use serum designed for targeted wrinkle care. Both contain NEI-L1®.

Is Medical Serum Duo allergy tested?

Yes. POLA states that the product has been allergy tested, although this does not guarantee that allergic reactions will not occur in every individual.