{"product_id":"haku-melanofocus-iv-45g","title":"HAKU Melanofocus IV 45g","description":"\u003ch3 dir=\"ltr\" class=\"tw-data-text tw-text-large tw-ta\"\u003eAbout Product\u003c\/h3\u003e\n\u003ch1\u003eSHISEIDO HAKU Melanofocus IV Medicated Brightening Serum 45g\u003c\/h1\u003e\n\u003cp\u003eDiscover advanced Japanese dark spot prevention with \u003cspan\u003eSHISEIDO HAKU Melanofocus IV\u003c\/span\u003e, a medicated brightening serum developed through more than two decades of SHISEIDO's pigmentation research.\u003c\/p\u003e\n\u003cp\u003eLaunched in February 2025, this advanced formula combines \u003cspan\u003ethree approved active ingredients\u003c\/span\u003e, including two brightening actives—Tranexamic Acid and 4MSK—to help suppress melanin production and prevent dark spots and freckles. A third active ingredient, Dipotassium Glycyrrhizate, helps prevent skin irritation.\u003c\/p\u003e\n\u003cp\u003eDesigned for those seeking serious dark spot prevention, HAKU Melanofocus IV features a smooth, melting texture that blends effortlessly into the skin, leaving it feeling moisturised and comfortable.\u003c\/p\u003e\n\u003cp\u003ePart of Japan's leading HAKU brightening serum range, Melanofocus IV brings together the brand's evolving skincare research in one sophisticated daily treatment.\u003c\/p\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003eKey Benefits\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eMedicated Japanese brightening serum for dark spot prevention\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eContains three approved active ingredients\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eTranexamic Acid helps suppress melanin production\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e4MSK helps prevent dark spots and freckles\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eDipotassium Glycyrrhizate helps prevent skin irritation\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eDeveloped using SHISEIDO's advanced pigmentation research\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eHelps maintain a clear, radiant-looking complexion\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eSmooth, melting texture that blends comfortably into the skin\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eProvides moisturising care alongside medicated brightening benefits\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eSuitable for incorporating into a daily dark spot prevention routine\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003ePart of HAKU's award-winning Melanofocus serum series\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003eThree Active Ingredients for Advanced Dark Spot Prevention\u003c\/h2\u003e\n\u003cp\u003eHAKU Melanofocus IV features a combination of three Japanese quasi-drug active ingredients, addressing both melanin production and skin irritation.\u003c\/p\u003e\n\u003ch3\u003e1. Tranexamic Acid (m-Tranexamic Acid)\u003c\/h3\u003e\n\u003cp\u003eTranexamic Acid is an approved Japanese brightening active ingredient used to help suppress melanin production and prevent the formation of dark spots and freckles.\u003c\/p\u003e\n\u003cp\u003eIn HAKU Melanofocus IV, it forms part of the serum's dual-active brightening approach.\u003c\/p\u003e\n\u003ch3\u003e2. 4MSK (Potassium 4-Methoxysalicylate)\u003c\/h3\u003e\n\u003cp\u003e4MSK is another approved Japanese brightening active developed by SHISEIDO.\u003c\/p\u003e\n\u003cp\u003eIt helps suppress melanin production, contributing to the prevention of dark spots and freckles.\u003c\/p\u003e\n\u003cp\u003eBy combining \u003cspan\u003eTranexamic Acid and 4MSK\u003c\/span\u003e, HAKU Melanofocus IV incorporates two complementary medicated brightening ingredients into a single formula.\u003c\/p\u003e\n\u003ch3\u003e3. Dipotassium Glycyrrhizate\u003c\/h3\u003e\n\u003cp\u003eDipotassium Glycyrrhizate is included as an active ingredient to help prevent skin irritation.\u003c\/p\u003e\n\u003cp\u003eIts presence complements the brightening ingredients by supporting the prevention of skin roughness and irritation.\u003c\/p\u003e\n\u003cp\u003eTogether, these three actives form the foundation of HAKU Melanofocus IV's medicated skincare approach.\u003c\/p\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003eDeveloped Through Over 20 Years of SHISEIDO Research\u003c\/h2\u003e\n\u003cp\u003eThe HAKU Melanofocus series began in 2005 and has continued to evolve alongside SHISEIDO's research into pigmentation and dark spot prevention.\u003c\/p\u003e\n\u003cp\u003eMelanofocus IV represents the brand's latest generation of medicated brightening care, incorporating research developed since the original Melanofocus serum.\u003c\/p\u003e\n\u003cp\u003eRather than focusing only on existing visible pigmentation, HAKU emphasises \u003cspan\u003epreventative skincare\u003c\/span\u003e, helping reduce the formation of new dark spots and freckles by suppressing melanin production.\u003c\/p\u003e\n\u003cp\u003eThis makes the serum particularly relevant for those who want to establish a consistent, long-term brightening skincare routine.\u003c\/p\u003e\n\u003cp\u003eThe product's approved brightening benefits concern melanin suppression and dark spot prevention. It should not be understood as a treatment that removes existing pigmentation or changes the skin's natural colour.\u003c\/p\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003eSHISEIDO's Advanced Pigmentation Research\u003c\/h2\u003e\n\u003cp\u003eHAKU's product development draws on SHISEIDO's continuing research into the biological processes associated with pigmentation.\u003c\/p\u003e\n\u003cp\u003eOne highlighted area of research involves analysing the energy-production state of living skin cells in real time.\u003c\/p\u003e\n\u003cp\u003eUsing a specialised evaluation method involving \u003cspan\u003eFluorescence Lifetime Imaging Microscopy (FLIM)\u003c\/span\u003e, SHISEIDO researchers investigated cellular metabolism in pigmented areas of the epidermis.\u003c\/p\u003e\n\u003cp\u003eThe research identified reduced cellular energy-production activity in the studied pigmented areas.\u003c\/p\u003e\n\u003cp\u003eSHISEIDO describes this evaluation method as a world-first application, based on a Clarivate assessment dated September 2024. The related research was also recognised at an International Federation of Societies of Cosmetic Chemists (IFSCC) scientific event.\u003c\/p\u003e\n\u003cp\u003eThese findings provide background to SHISEIDO's broader pigmentation research. They should not be interpreted as clinical proof that Melanofocus IV restores cellular energy production or removes established dark spots.\u003c\/p\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003eSmooth, Melting Serum Texture\u003c\/h2\u003e\n\u003cp\u003eHAKU Melanofocus IV is designed to melt smoothly into the skin, making it comfortable to incorporate into an everyday skincare routine.\u003c\/p\u003e\n\u003cp\u003eIts refined texture spreads easily across the complexion while providing moisturising care.\u003c\/p\u003e\n\u003cp\u003eThe serum is particularly appealing for those who prefer a brightening treatment that feels comfortable on the skin rather than heavy or overly rich.\u003c\/p\u003e\n\u003cp\u003eWith regular use, it supports an ongoing preventative approach to pigmentation concerns while helping maintain a moisturised, radiant-looking appearance.\u003c\/p\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003eAn Award-Winning Japanese Brightening Serum Series\u003c\/h2\u003e\n\u003cp\u003eHAKU has established a strong reputation in Japan's brightening skincare category since the original Melanofocus launched in 2005.\u003c\/p\u003e\n\u003cp\u003eAccording to Intage SRI and SRI+ retail sales data, \u003cspan\u003eHAKU ranked No. 1 in Japan's brightening serum market by sales value for 21 consecutive years\u003c\/span\u003e, covering January 2005 to December 2025.\u003c\/p\u003e\n\u003cp\u003eThe Melanofocus series has also received \u003cspan\u003e174 beauty awards since March 2005\u003c\/span\u003e, according to SHISEIDO's published brand information.\u003c\/p\u003e\n\u003cp\u003eAmong its recent recognitions, HAKU Melanofocus IV received first place in the \u003cspan\u003eVOCE Best Cosme 2025 Autumn\/Winter Readers' Choice category for dark spot and dullness concerns\u003c\/span\u003e.\u003c\/p\u003e\n\u003cp\u003eThese achievements reflect the brand's longstanding presence in Japanese beauty and its popularity among consumers and beauty publications.\u003c\/p\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003eWho Is It For?\u003c\/h2\u003e\n\u003cp\u003eHAKU Melanofocus IV may be particularly appealing to those who:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eWant to prioritise prevention of new dark spots and freckles\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eAre concerned about uneven-looking pigmentation\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003ePrefer skincare with approved medicated active ingredients\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eWant a brightening serum supported by SHISEIDO's research\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eAre looking for a moisturising serum that blends smoothly into the skin\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eWant to maintain a clearer, more radiant-looking complexion\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003ePrefer a preventative approach to long-term pigmentation care\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eHAKU also presents the serum as an option for people considering dark spot prevention after cosmetic laser procedures. However, suitability immediately after treatment is not established by the supplied product information. Follow your dermatologist's instructions before introducing active skincare after a procedure.\u003c\/p\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003eHow to Use\u003c\/h2\u003e\n\u003cp\u003eIncorporate HAKU Melanofocus IV into your regular facial skincare routine.\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eCleanse your face and apply your usual lotion or toner.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eDispense an appropriate amount of serum.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eGently spread across the face, paying attention to areas of pigmentation concern.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eAllow the serum to settle before continuing with your moisturiser.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003eDuring the day, finish your skincare routine with broad-spectrum sunscreen.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003cspan\u003eThe supplied information references an official application video but does not specify the exact dosage or application sequence in text. The steps above are general serum-use guidance rather than a verified transcription of HAKU's official directions.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eFor effective dark spot prevention, daily sun protection remains an important part of skincare.\u003c\/p\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003eProduct Details\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eBrand:\u003c\/span\u003e SHISEIDO HAKU\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eProduct Name:\u003c\/span\u003e Melanofocus IV\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eJapanese Name:\u003c\/span\u003e HAKU メラノフォーカス IV\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eCategory:\u003c\/span\u003e Medicated Brightening Serum\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eClassification:\u003c\/span\u003e Japanese Quasi-Drug (医薬部外品)\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eNet Weight:\u003c\/span\u003e 45g\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eRelease Date:\u003c\/span\u003e February 2025\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eBrightening Active 1:\u003c\/span\u003e Tranexamic Acid (m-Tranexamic Acid)\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eBrightening Active 2:\u003c\/span\u003e 4MSK (Potassium 4-Methoxysalicylate)\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eAnti-Irritation Active:\u003c\/span\u003e Dipotassium Glycyrrhizate\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003ePrimary Benefit:\u003c\/span\u003e Helps suppress melanin production to prevent dark spots and freckles\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eAdditional Benefit:\u003c\/span\u003e Helps prevent skin irritation\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eTexture:\u003c\/span\u003e Smooth, Melting Serum\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv\u003e\n\u003cdiv\u003e\n\u003cp\u003e\u003cspan\u003eSkincare Focus:\u003c\/span\u003e Dark Spot Prevention \u0026amp; Moisturising Care\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003ch2\u003ePeople Also Ask\u003c\/h2\u003e\n\u003ch3\u003eWhat does HAKU Melanofocus IV do?\u003c\/h3\u003e\n\u003cp\u003eHAKU Melanofocus IV is a medicated brightening serum that helps \u003cspan\u003esuppress melanin production to prevent dark spots and freckles\u003c\/span\u003e. It also contains an active ingredient that helps prevent skin irritation.\u003c\/p\u003e\n\u003ch3\u003eWhat are the active ingredients in HAKU Melanofocus IV?\u003c\/h3\u003e\n\u003cp\u003eThe serum contains three approved active ingredients: \u003cspan\u003eTranexamic Acid, 4MSK and Dipotassium Glycyrrhizate\u003c\/span\u003e. The first two target melanin production, while the third helps prevent skin irritation.\u003c\/p\u003e\n\u003ch3\u003eCan HAKU Melanofocus IV remove existing dark spots?\u003c\/h3\u003e\n\u003cp\u003eIts approved brightening benefit is to help prevent dark spots and freckles by suppressing melanin production. It is not a medical treatment for removing existing pigmentation.\u003c\/p\u003e\n\u003ch3\u003eWhat is the difference between HAKU Melanofocus IV and previous Melanofocus serums?\u003c\/h3\u003e\n\u003cp\u003eMelanofocus IV is the February 2025 generation of HAKU's long-running brightening serum series. It incorporates the brand's evolving pigmentation research and features three medicated active ingredients. A precise formula-by-formula comparison would require the ingredient information for earlier versions.\u003c\/p\u003e\n\u003ch3\u003eIs HAKU Melanofocus IV suitable for daily use?\u003c\/h3\u003e\n\u003cp\u003eIt is positioned as a regular brightening skincare treatment. Follow the directions on the product packaging and use appropriate sunscreen during the day.\u003c\/p\u003e","brand":"HAKU","offers":[{"title":"Default Title","offer_id":54597511741758,"sku":null,"price":65.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0777\/9359\/1614\/files\/HAKUMelanofocusIV45g.jpg?v=1791698972","url":"https:\/\/tokyobeautybox.com\/zh\/products\/haku-melanofocus-iv-45g","provider":"Tokyo Beauty Box","version":"1.0","type":"link"}